43 Oral Sildenafil in the Treatment of Erectile Dysfunction
Learn more sildenafil 12 5 mg about some of the side effects that sildenafil may cause.
Authors' conclusions
However, the exact reason why these side effects occurred is not fully known. If you have any sudden changes in your vision or hearing, talk with your doctor right away. Also talk with them if you’re concerned about long-term side effects with sildenafil treatment. * To learn more about the clinical trials of sildenafil, refer to the drug’s prescribing information for erectile dysfunction and pulmonary arterial hypertension. † For more details about these side effects, including their symptoms, see the “Sildenafil: Serious side effects” section above. To find out how often side effects occurred in clinical trials, see the drug’s prescribing information for erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). However, this side effect was rare in clinical trials. * Sildenafil is a vasodilator, meaning it widens the blood vessels and makes it easier for blood to flow. When this happens, your blood pressure may drop. This is because your heart doesn’t have to work as hard to move blood around your body. Signs and symptoms of low blood pressure include tiredness, lightheadedness, or blurry vision. They may also include nausea, dizziness, fainting, and confusion.
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Low blood pressure can be mild or severe depending on how much your blood pressure drops.
What is sildenafil?
With priapism, you experience a continued (4 hours or longer) erection that’s often painful. For more information about this side effect, see the “Sildenafil: Side effect specifics” section below. Use of the term “female” and “male” in this article refers to sex assigned at birth. It’s possible to develop long-term side effects from sildenafil treatment. In clinical trials,* long-term side effects, such as vision loss and hearing loss,† occurred at any time during treatment. You may have an increased risk of severe low blood pressure if you: already take drugs to lower your blood pressure have a blood pressure less than 90/50 before taking sildenafil If you take blood pressure drugs during sildenafil treatment, your doctor will recommend monitoring your blood pressure regularly. If you notice any signs or symptoms of low blood pressure while taking sildenafil, talk with your doctor. They’ll review your symptoms and other medications to make sure it’s safe for you to keep taking the drug.
- Women are generally not treated with sildenafil for sexual arousal.
- Research on sildenafil's effects on women is ongoing.
- Use in women should only occur under medical supervision.
* To learn more about the clinical trials of sildenafil, refer to the drug’s prescribing information for ED and PAH. Headache is a possible side effect while taking sildenafil. Headaches were common and typically mild in clinical trials of the drug.* If you start to experience headaches often or if they affect your daily life, talk with your doctor.
Other uses for this medicine
You can experience mild or severe side effects from sildenafil with any dosage. However, you may have an increased risk of side effects with higher dosages. If you start to experience side effects that become bothersome or severe while taking sildenafil, talk with your doctor. Here are some frequently asked questions about the drug’s side effects and their answers. No, there aren’t any reviews from people who’ve taken 50-milligram (mg) or 100-mg sildenafil tablets.
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However, you may experience mild or severe side effects from sildenafil with any prescribed dose. In clinical trials,* a similar number of people reported certain side effects with both 50-mg and 100-mg doses. These side effects included mild to moderate headaches, flushing, and back pain. However, people taking the 100-mg dose had an increased risk of upset stomach, vision changes, and runny nose. If you have questions about the side effects of your prescribed sildenafil dose, talk with your doctor or pharmacist.
Product Overview
* To learn more about the clinical trials of sildenafil, refer to the drug’s prescribing information for erectile dysfunction and pulmonary arterial hypertension (PAH). No, sildenafil isn’t known to cause different side effects in females. * Sildenafil is approved to treat PAH in most adults, including females. If you’re female and concerned about side effects with sildenafil, talk with your doctor. Note: If you’re male, priapism may occur during sildenafil treatment. They may recommend lifestyle changes, such as more rest to help ease your headache. Your doctor may also recommend pain medications to help treat your headache. These may include ibuprofen (Advil, Motrin) or acetaminophen (Tylenol). Severe cardiovascular problems may occur during sildenafil treatment. This side effect was reported* in people taking sildenafil for ED after the drug was approved. Cardiovascular problems, such as heart attack, stroke, irregular heartbeat, lung bleeding, and brain bleeding were rarely reported. Many of these reported side effects occurred during or shortly after sexual activity. Most of the people who experienced cardiovascular problems during sildenafil treatment already had other heart-related conditions. So it’s unknown if sildenafil was the direct cause of these side effects.
- Patients with heart conditions should consult a cardiologist before use.
- Sildenafil may cause a temporary drop in blood pressure.
- Do not use sildenafil if you have a history of stroke or heart attack.
They may be due to other factors, such as preexisting heart disease, sexual activity, or a combination of these factors. Before you start sildenafil treatment, be sure to tell your doctor if you have any heart conditions. Depending on your heart health, sildenafil may not be safe for you to take.
| Medication Type | Potential Interaction | Effect | Notes |
|---|---|---|---|
| Nitrates | Severe hypotension | Dangerous drop in blood pressure | Absolute contraindication |
| Alpha-blockers | Enhanced hypotensive effect | Blood pressure may drop too low | Use with caution, monitor BP |
| CYP3A4 inhibitors | Increased sildenafil levels | Increased risk of side effects | Dose adjustment may be needed |
| Rifampin | Reduced sildenafil effectiveness | Lower plasma levels | May require dose increase |
Your doctor can review the risks and benefits of taking sildenafil to determine the right treatment plan for you. If you’re interested in having sex while taking sildenafil for ED or PAH, talk with your doctor before starting treatment. It’s important to talk with your doctor about your heart health before having sex.
- Sildenafil can improve exercise capacity in pulmonary hypertension patients.
- Regular monitoring may be required for long-term use.
- Be aware of potential side effects related to blood pressure changes.
Engaging in sexual activity when you have heart problems may increase your risk of severe cardiovascular problems, including heart attack.
Material and Methods
† An allergic reaction is possible after taking sildenafil. However, this side effect was rarely reported in clinical trials of sildenafil for ED and PAH. To learn more, see the “Sildenafil: Side effect specifics” section below. The list below may not include all possible serious side effects of the drug. If you develop serious side effects while taking sildenafil, call your doctor right away.
Other Medical Problems
If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number. Serious side effects that have been reported and their symptoms include: Symptoms can include:tinnitus (ringing in your ear)dizzinessdecrease in hearing Symptoms can include:trouble seeing in either eyeblurry visionseeing eye floaters * To learn more about this side effect, see the “Sildenafil: Side effect specifics” section below. Sildenafil is not approved by the Food and Drug Administration (FDA) for use in children. In clinical trials, children who were given sildenafil long term to treat pulmonary arterial hypertension had an increased risk of fatality. However, your child’s doctor may recommend taking sildenafil off-label in some cases.
Sildenafil Tablets for ED
(With off-label use, a doctor prescribes an FDA-approved drug for a purpose other than what it’s approved for.) Talk with your child’s doctor to determine if sildenafil is right for your child. They can help compare the risks and benefits of the drug. Sildenafil oral tablets come in different strengths: 20 milligrams (mg), 25 mg, 50 mg, and 100 mg. The dosage you’re prescribed will depend on what condition you’re taking sildenafil for. It also depends on how the dosage is working for you. This risk may increase further if you take sildenafil, have heart problems, and have sex.
Adverse effects
Your doctor can also tell you more about sildenafil. Sildenafil can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. These are just a few of the more common side effects reported by people who took sildenafil in clinical trials:* * To learn more about the clinical trials of sildenafil, refer to the drug’s prescribing information for erectile dysfunction and pulmonary arterial hypertension.
More common
† For more information about this side effect, see “Sildenafil: Side effect specifics” below. Optum Perks is owned by RVO Health. By clicking on this link, we may receive a commission. Mild side effects can occur with sildenafil use. This list doesn’t include all possible mild side effects of the drug.
Marketing and sales
For more information, you can refer to sildenafil’s prescribing information for erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). Mild side effects that have been reported with sildenafil include: These side effects may be temporary, lasting a few days to weeks. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you develop a side effect while taking sildenafil and want to tell the FDA about it, visit MedWatch. * For more information about this side effect, see “Sildenafil: Side effect specifics” below. Your doctor can review the risks and benefits of having sex during sildenafil treatment. Nosebleeds are a common side effect of sildenafil, and they’re typically mild. In clinical trials,* people who were taking warfarin (Jantoven) had an increased risk of nosebleeds. Symptoms of nosebleeds include bleeding from one or both nostrils. It also includes feeling as if you have to swallow a lot. If you start to experience nosebleeds often or if they don’t stop, talk with your doctor. They may recommend applying a cold cloth to the bridge of your nose briefly or pinching your nostrils for a short period of time. Your doctor may also recommend medications to help with nosebleeds, such as oxymetazoline (Afrin). It usually happens without sexual stimulation or continues long after sex. Priapism was a rare side effect in clinical trials of sildenafil.* Priapism can become a serious side effect if your erection lasts longer than 4 hours. If you’ve ever had sickle cell anemia, multiple myeloma, or leukemia, you may have an increased risk of developing severe priapism.