ADVERSE REACTIONS
Practice "safe sex" such as using latex condoms.
| Condition | Risk Factors | Recommendations |
|---|---|---|
| Use with nitrates | Severe hypotension, risk of significant blood pressure drop | Avoid combining, consult healthcare provider |
| Severe cardiovascular disease | Risk of adverse cardiovascular events | Use only under medical supervision |
| Liver impairment | Altered metabolism, increased side effects | Dose adjustment or avoid use |
| Retinitis pigmentosa | Potential for increased visual side effects | Use with caution, consult ophthalmologist |
Consult your doctor or pharmacist for more details. Sildenafil is also available in other brands and strengths for treating high blood pressure in the lungs (pulmonary hypertension).
| Parameter | Value | Notes |
|---|---|---|
| Absorption Rate | Rapid | Peak plasma levels in ~60 minutes |
| Bioavailability | Approximately 40% | Due to first-pass metabolism |
| Half-life | About 4 hours | Time to reduce plasma concentration by half |
| Metabolism | Liver (primarily via CYP3A4) | Enzymatic breakdown |
| Excretion | Mainly feces (~80%) | Some via urine (~13%) |
Do not take sildenafil with any other product that contains sildenafil or other similar medications for erectile dysfunction-ED or pulmonary hypertension (such as tadalafil, vardenafil).
Before Using
Some men also reported increased erectile functioning the next day. Forty-three percent of men with radical prostatectomy reported improvement in erections after taking sildenafil compared with 15 percent after taking placebo. Sildenafil lowers blood pressure slightly in normal patients and substantially in patients who are undergoing nitrate therapy for angina. The most common side effects are headache, flushing and dyspepsia. Transient abnormal vision, usually a color tinge or increased sensitivity to light, is uncommon and is usually dose-related.
The Bottom Line
No incidence of priapism has been reported. Sildenafil should be used cautiously in patients taking cimetidine, erythromycin, rifampin and ketoconazole. Sildenafil is available in 25-, 50- and 100-mg tablets. The manufacturer sildenafil products over the counter recommends an initial dosage of 50 mg (which can be increased to 100 mg if necessary) taken one hour before intercourse. Patients older than 65 years of age, those with hepatic or renal dysfunction and those who are taking a CYP3A4 inhibitor should start with a 25-mg dosage. Sildenafil is available under the following different brand names: Revatio, and Viagra.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Polo | 100mg | 12 Pills | 60.21€ 57.34€ | |
| Viagra Generic | 50mg | 20 Pills | 40.52€ 38.59€ | |
| Viagra Generic | 50mg | 30 + 4 Pills | 54.26€ 51.68€ | |
| Viagra Generic | 200mg | 90 + 6 Pills | 170.79€ 162.66€ | |
| Kamagra Polo | 100mg | 20 Pills | 83.56€ 79.58€ | |
| Viagra Generic | 100mg | 10 Pills | 28.91€ 27.53€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Kamagra Polo | 100mg | 120 + 6 Pills | 327.15€ 311.57€ | |
| Viagra Generic | 25mg | 30 + 4 Pills | 47.97€ 45.69€ | |
| Viagra Generic | 100mg | 30 + 4 Pills | 60.91€ 58.01€ | |
| Kamagra Soft Tabs | 100mg | 60 + 4 Pills | 180.59€ 171.99€ | |
| Viagra Generic | 100mg | 60 + 4 Pills | 96.36€ 91.77€ |
Dosage Considerations – Should be Given as Follows: 50 mg orally 1 hour before sexual activity may be increased to 100 mg or reduced to 25 mg, depending on effectiveness and tolerance Oral: 5 mg or 20 mg 3 times daily, administered 4-6 hours apart Intravenous (IV): 2.5-mg or 10-mg bolus 3 times daily if patient is temporarily unable to take orally Recommended oral/IV dose not to be exceeded Adding Revatio to bosentan does not have any beneficial effect on exercise capacity Hepatic impairment or severe renal impairment: Use initial dose of 25 mg Older than 65 years: 25 mg orally initially 1 hour before sexual activity Oral: 5 mg or 20 mg 3 times daily, administered 4-6 hours apart Intravenous (IV): 2.5-mg or 10-mg bolus 3 times daily if patient is temporarily unable to take orally Recommended oral/IV dose not to be exceeded Adding Revatio to bosentan does not have any beneficial effect on exercise capacity Clinical trials found no significant difference in response between elderly patients and younger adults; however, cautious dose selection should be considered in elderly because of greater frequency of decreased hepatic, renal, and cardiac function, as well as comorbid conditions and concomitant pharmacotherapy Compared with healthy younger volunteers, healthy elderly volunteers (65 years and older) had reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma concentrations of sildenafil and its active N-desmethyl metabolite, respectively Not to be prescribed to children (1-17 years) for pulmonary arterial hypertension (PAH); this recommendation against use is based on long-term clinical pediatric trial showing that children taking high doses had higher risk of death than children taking low doses and that low doses were not effective in improving exercise ability Side effects associated with use of Sildenafil, include the following: Postmarketing side effects of sildenafil reported include: Vaso-occlusive crisis (PAH secondary to sickle-cell anemia) This document does not contain all possible side effects and others may occur.
Usual Adult Dose for Erectile Dysfunction
If you don’t want to have to coordinate sex with the timing of your tablets, the best option might be the longer-acting tadalafil 10mg tablet. Note, however, that this is not intended for continuous use – it’s to be taken as needed. For continuous use, the lower daily doses are more appropriate, and enables you to have completely spontaneous sex. If, however, you have sex more infrequently or are troubled by the idea of taking a daily tablet, sildenafil might be a better choice. To find out whether sildenafil or tadalafil might be suitable for you, you can start a consultation here. Check with your physician for additional information about side effects.
- Medication effectiveness can be impacted by certain health conditions.
- Men should not use sildenafil if they have a history of stroke.
- Sildenafil 10mg can sometimes cause nasal congestion.
- It’s important to report any unusual side effects to your doctor.
- Do not use sildenafil if you are taking other ED medications.
If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. Sildenafil has serious interactions with at least 48 different drugs.
Other Comments
Sildenafil and tadalafil are both well-researched treatments for erectile dysfunction which are generally safe and effective. Which you use depends mainly on which is the best fit for your personal needs and lifestyle. Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual sildenafil tables stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection. Sildenafil does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Sildenafil has moderate interactions with at least 72 different drugs.
The Medically Approved Combination – A Sublingual Option
Only one published study of sildenafil using objective measurements has been conducted. Plethysmographic measurements were obtained in 12 men with erectile dysfunction in a randomized, controlled crossover study. The mean duration of erections was about one minute with placebo, four minutes with 10 mg of sildenafil, about eight minutes with 25 mg and eight to 11 minutes with 50 mg of active drug. The men were instructed to record erectile activity after taking 25 mg of sildenafil or placebo once daily for seven days. The number of erections within two hours after taking sildenafil was about five times greater with the active drug than with placebo.
Can vardenafil and sildenafil be taken together?
Other unpublished studies evaluated men with erectile dysfunction who took 25, 50 or 100 mg of sildenafil or placebo at home for up to six months. The drug did not affect the frequency of attempted intercourse. However, in four fixed-dose trials, improvement in erections was reported by 63 percent of the 214 men taking 25 mg of sildenafil, 74 percent of the 391 men taking 50 mg and 82 percent of the 380 men taking 100 mg of the drug. Twenty-four percent of the 463 men taking placebo experienced improvement in erectile functioning. The effect was detectable as soon as 30 minutes after taking the drug and lasted up to four hours. This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use.
- Reduced dosage like 10mg is suitable for sensitive individuals.
- Common side effects include headaches and flushing.
- Sildenafil should not be taken with nitrate medications.
- Avoid heavy meals before taking sildenafil for quicker action.
- The effects of 10mg can last up to 4-6 hours.
Keep a list of all your medications with you, and share this information with your doctor and pharmacist.
Drug Interactions
It was developed after sildenafil, and has a faster onset of action (starts working in 30 minutes) and duration of action (stays in your system for 36 hours). PDE5 is an sildenafil 100g enzyme that acts to allow your erection to subside after sex. When inhibited, a stronger and longer-lasting erection is possible for those with erectile dysfunction. Sildenafil and tadalafil do not affect sexual desire. In order to have the desired effect, you still need to be sexually aroused.
Special Populations
Tadalafil works a little faster than sildenafil, and lasts longer. This doesn’t mean it’s a stronger drug – it just works differently. Sildenafil takes effect in about an hour, where tadalafil usually starts working in half an hour. Combined trial results worldwide show that both medications are similarly safe and effective – there is no significant difference between the two – though men seem to prefer tadalafil slightly overall. Ultimately the choice comes down to what is the best fit for your lifestyle. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
| Brand/Source | Price per Tablet | Package Size | Cost per Pack | Notes |
|---|---|---|---|---|
| Brand A | $3.00 | 30 tablets | $90.00 | Trademarked, pharmacy purchase |
| Generic B | $0.50 | 60 tablets | $30.00 | FDA-approved generic |
| Online Supplier C | $0.20 | 90 tablets | $18.00 | Bulk purchase, check authenticity |
| Local Pharmacy D | $1.00 | 20 tablets | $20.00 | Over-the-counter available |
Do not take Revatio or Viagra if you are allergic to sildenafil or any ingredients contained in this drug.
- The pill should be swallowed whole with water.
- Use caution if you have liver or kidney disease.
- Synergistic effects can occur with other blood pressure medications.
- Sildenafil is not a sexual stimulant; stimulation is required.
- Always read the patient information leaflet thoroughly before use.
In case of overdose, get medical help or contact a Poison Control Center immediately Soluble guanylate cyclase (sGC) stimulators (e.g., riociguat); concomitant use can cause hypotension Co-administration with nitrates (either regularly and/or intermittently) and nitric oxide donors Consistent with the effects of PDE5 inhibition on the nitric oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors may potentiate the hypotensive effects of nitrates A suitable time interval following PDE5 dosing for the safe administration of nitrates or nitric oxide donors has not been determined Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure.
What other drugs will affect sildenafil?
Sildenafil should not be taken more than once a day. The cost to the pharmacist for 30 tablets of any size is about $263. Medical Letter consultants conclude that sildenafil appears to be an effective oral drug for treatment of erectile dysfunction, although not all patients respond, and long-term safety has not been established. The hypotensive effects may be troublesome in some patients; persons using nitrates for treatment of angina should not take sildenafil. Sildenafil and tadalafil are similar medications used to treat erectile dysfunction.
Storage Class
If you’re having trouble deciding which one’s right for you, this article might help you with your choice. Sildenafil is the generic name for Viagra, a brand name belonging to one of the manufacturers of the drug. Sildenafil is the original and still best-known treatment for erectile dysfunction. It starts working an hour after you take it, and stays in your system for 4 hours within which you can expect a stronger and longer-lasting erection when sexually aroused. Tadalafil is the generic name for Cialis, a drug which works similarly to sildenafil. See "What Are Side Effects Associated with Using Sildenafil?"